程控形变的血管组织工程支架进展

心血管疾病是当前人类生命健康的首要威胁。血管组织工程支架可用于病变血管的再生修复，为心血管疾病治疗提供了选择。然而，现有血管组织工程支架尚面临界面适配的挑战，导致植入后易发生并发症而难以被临床转化。最近研发的具有程控形变能力的血管组织工程支架不但可动态适应不同尺寸的血管三维形态，而且可有序引导血管细胞的行为功能，为解决血管组织工程支架界面适配难题提供了机遇。作者对程控形变血管组织工程支架的最新研究进展和现存挑战进行综述和展望，有望为新一代组织工程血管支架的研发和转化提供启示。

A Brief Overview of Programmed Deformed Scaffolds for Vascular Tissue Engineering

Cardiovascular disease is one of leading threats to human life and health. Scaffolds for vascular tissue engineering that can assist the regeneration and repair of disordered vessels have provided promising alternatives for cardiovascular disease treatment. However, existing scaffolds for vascular tissue engineering still confront grand challenges in interfacial adaptations, resulting in high risks of complications upon implantation and unsatisfactory translational application. Recently, scaffolds for vascular tissue engineering capable of programmed deformation have been emerging. Such scaffolds can not only dynamically adapt to three-dimensional vascular shapes with varying diameters but also orderly regulate behaviors and functions of vascular cells, offering new opportunities for addressing the grand challenges of interfacial adaptations. An overview of most-updated advances and perspectives of programmed deformed scaffolds for vascular tissue engineering will provide valuable inspirations to the development and translational applications of new generation of scaffolds for vascular tissue engineering.