Effect of fMRI acoustic noise on non-auditory working memory task: comparison between continuous and pulsed sound emitting EPI |
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Authors: | Sven Haller Andreas J Bartsch Ernst W Radue Markus Klarhöfer Erich Seifritz Klaus Scheffler |
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Affiliation: | (1) Institute of Neuroradiology, Department of Medical Radiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland;(2) Department of Neuroradiology, University of Würzburg, Würzburg, Germany;(3) MR Physik, Department of Medical Radiology, University Hospital Basel, Basel, Switzerland;(4) University Hospital of Clinical Psychiatry, University of Berne, Berne, Switzerland |
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Abstract: | Conventional blood oxygenation level-dependent (BOLD) based functional magnetic resonance imaging (fMRI) is accompanied by
substantial acoustic gradient noise. This noise can influence the performance as well as neuronal activations. Conventional
fMRI typically has a pulsed noise component, which is a particularly efficient auditory stimulus. We investigated whether
the elimination of this pulsed noise component in a recent modification of continuous-sound fMRI modifies neuronal activations
in a cognitively demanding non-auditory working memory task. Sixteen normal subjects performed a letter variant n-back task. Brain activity and psychomotor performance was examined during fMRI with continuous-sound fMRI and conventional
fMRI. We found greater BOLD responses in bilateral medial frontal gyrus, left middle frontal gyrus, left middle temporal gyrus,
left hippocampus, right superior frontal gyrus, right precuneus and right cingulate gyrus with continuous-sound compared to
conventional fMRI. Conversely, BOLD responses were greater in bilateral cingulate gyrus, left middle and superior frontal
gyrus and right lingual gyrus with conventional compared to continuous-sound fMRI. There were no differences in psychomotor
performance between both scanning protocols. Although behavioral performance was not affected, acoustic gradient noise interferes
with neuronal activations in non-auditory cognitive tasks and represents a putative systematic confound |
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Keywords: | BOLD Acoustic noise Working memory Distraction Attention |
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