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Synthesis of new phosphate derivative of benzothiazole and its inhibiting effect on two series of human neuroblastoma cell growth |
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| Authors: | Mahshid Nikpour Nezhati Gholam Hossein Riazi Homayon Ahmad Panahi Elham Moniri Nasir Ahmad Rajabi Mohammad Mehdi Sadughi Natasha Rahmani Zaker Robab Ardekani Reihaneh Kooshkestani |
| Affiliation: | 1191. Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran 2191. Department of Pharmacology, Tehran University, Tehran, Iran 3191. Department of Chemistry, Islamic Azad University, Varamin Branch (Pishva), Iran 4191. Department of Chemistry, Imam Khomeini International University (IKIU), Qazvine, Iran 5191. Young Researchers Club, Islamic Azad University, Central Tehran Branch, Tehran, Iran 6191. Young Researchers Club, Islamic Azad University, Ghaemshahr Branch, Tehran, Iran 7191. Department of Microbiology, Islamic Azad University, Science and Research Campus, Tehran, Iran 8191. Department of Biochemistry, Alzahra University, Tehran, Iran |
| Abstract: | The sodium salt of di ((1-hydroxy-2-benzothiazolium-1-yl) ethyliden-1,1-H-bisphosphonic acid) orthophosphate was synthesized and its toxicity and viability effects screened on two different human neuroblastoma cell lines. This novel derivative of benzothiazole provides a new compound in connection with research and therapeutic application for tumor cell growth inhibition. Benzothiazole was alkylated in reaction with bromoacetic acid and then converted to its H-bisphosphonic acid derivative in presence of H3PO3/POCl3. The procedure led to formation of two molecules of corresponding H-bisphosphonic acid which attached together via a phosphate bridge. The investigated compound exhibits activities (IC50 value) ranging from 14–23 μM (corresponding to human neuroblastoma SK-BE (2) and SK-NM-C cells). |
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