Enhanced transdermal deposition and characterization of quercetin-loaded ethosomes |
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Authors: | Soo Nam Park Hye Jin Lee Hae Soo Kim Min A Park Hyun A Gu |
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Affiliation: | 1171. Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, Seoul, 139-743, Korea
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Abstract: | We sought to evaluate the transdermal permeation potential of quercetin-loaded ethosomes. Quercetinloaded ethosomes were prepared and characterized with regard to particle size, loading efficiency, stability, and in vitro skin permeation. The optimized formulation of ethosomes was confirmed using 2% egg phosphatidylcholine and hydrated 20% ethanol. After quercetin was applied using this formulation, the stability of the ethosomes was determined when loaded with up to 0.04% quercetin. We observed that loading efficiency was improved with increasing concentrations of quercetin. Ethosomes loaded with 0.04% quercetin showed both the greatest loading efficiency (63.9%±6.0%) and an optimal size range (132±32 nm). Ethosomes loaded with quercetin were superior in skin permeation ability (29.5±7.0 μg/cm2) compared to either ethanolic solution or liposomes. Therefore, we concluded that quercetin-loaded ethosomes increased the skin delivery of quercetin. Our results suggest that quercetin-loaded ethosomes may enhance the effect of cosmetic materials. |
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