Selective cytotoxic effect of ZnO nanoparticles on glioma cells |
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Authors: | Stella Ostrovsky Gila Kazimirsky Aharon Gedanken Chaya Brodie |
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Affiliation: | (1) I. Physics Institute, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 16, 35392 Giessen, Germany; |
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Abstract: | In this study we examined the cytotoxic effect of ZnO nanoparticles on various human cancer and normal cells. We found that
the ZnO nanoparticles exerted a cytotoxic effect on the human glioma cell lines A172, U87, LNZ308, LN18, and LN229, whereas
no cytotoxic effect was observed on normal human astrocytes. Similarly, the ZnO nanoparticles induced cell death in breast
and prostate cancer cell lines while no major effect was observed in the respective normal breast and prostate cell lines.
Using the fluorescent dye 2,7-dichlorofluorescein diacetate, we found that treatment of the glioma cells with ZnO nanoparticles
induced a large increase in the generation of reactive oxygen species (ROS) and treatment of the cells with N-acetyl cysteine decreased the cytotoxic effect of the ZnO nanoparticles. In contrast, a smaller effect on ROS generation
was observed in the normal astrocytes. These results suggest that ZnO nanoparticles may be employed as a selective cytotoxic
agent for the eradication of cancer cells. |
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