Antioxidant and antiproliferative activities of grape seeds from different cultivars |
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Authors: | Jeehye Sung Junsoo Lee |
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Affiliation: | (1) Division of Pharmacognosy, Section Metabolomics, Institute of Biology, Leiden University, Einsteinweg 55, P.O. Box 9502, 2333 CC Leiden, The Netherlands; |
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Abstract: | Grape seeds contain high levels of phytochemicals, which have been correlated with a decreased risk of chronic diseases. In
this study, grape seeds from 10 different cultivars (‘SV 18315’, ‘Naples’, ‘Agawam’, ‘Aligote’, ‘V.50151’, ‘Cabernet Sauvignon’,
‘Urbana’, ‘Baco22A’, ‘Clinton’, and ‘Campbell Early’) were evaluated for their antioxidant and antiproliferative activities.
The antioxidant activity of the grape seeds was evaluated by radical scavenging activities and reducing power. The antiproliferative
activity was assessed by the inhibition of MCF7, NCI-H460, HCT116, and MKN45 cancer cell proliferation. The total polyphenol
and flavonoid contents were determined by spectrophotometric methods. ‘Cabernet Sauvignon’ and ‘Baco22A’ had high polyphenol
(4,369.2 and 3,747.0 mg/100 g seeds) and flavonoid contents (3,072.7 and 2,032.9 mg/100 g seeds). ‘Cabernet Sauvignon’ and
‘Baco22A’ also possessed the highest radical scavenging activity. In addition, these were showed generally higher antiproliferative
activity than other cultivars. Both the polyphenol and flavonoid contents were positively correlated with radical scavenging
activity (R2>0.9). These results may provide basic information about health-beneficial effects of grape seeds. |
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