Retarding effects of DNA on the autoxidation of liposomal suspensions |
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| Authors: | Dennis D Pietronigro Myron L Seligman W Barrie G Jones Harry B Demopoulos |
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| Affiliation: | (1) Department of Pathology, New York University Medical Center, New York, New York |
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| Abstract: | Deoxyribonucleic acid (DNA) is associated with the cell membrane of prokaryotes and the inner nuclear membrane of eukaryotes.
The unsaturated fatty acids of phospholipids, which constitute the bilaminar structure of membranes, undergo autoxidation
in the presence of O2. Calf thymus DNA was incubated with methyl archidonate-enriched phosphatidyl choline liposomes in order to study the effect
of DNA upon the oxidation of phospholipids while present in their natural in vivo bilayer configuration. DNA retarded the
rate of lipid oxidation and the TBA test, but it did not alter the induction period. These results suggest that DNA is scavenging
free radicals produced within the phospholipid bilayer. |
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