ANTIBACTERIAL EFFECT, HISTOLOGICAL IMPACT AND OXIDATIVE STRESS STUDIES FROM LAURUS NOBILIS EXTRACT

Laurus nobilis is one of the most broadly used spices in Moroccan gastronomy. Its antimicrobial activity against both gram-positive and gram-negative bacterial species was demonstrated. Likewise, its toxicity was investigated on Swiss albinos' mice . Daily, mice were treated orally with 0.003 and 0.3 mg during 7 days. Plasmatic markers and enzymatic systems were assessed and histological alterations were evaluated. A significant increase in creatine phosphokinase level was observed. The microscopic evaluation showed that L. nobilis induces morphological perturbation in mice's liver. The results also showed an inhibitory effect of glyceraldehydes 3-phosphate dehydrogenase and an important increase in the level of thiobarbituric acid reactive substances and succinate dehydrogenase and no change in catalase activities. The results showed that L. nobilis induces toxicity at 0.3 mg/g mouse and affects energy metabolism and oxidative stress.

PRACTICAL APPLICATIONS

The aim of the present study is to determine the antimicrobial effect of Laurus nobilis on pathogens for potential application as herbal medicine in infusion or oral preparation. The effect of the spice extract was investigated on the metabolic markers, stress biomarkers and clinical parameters. This study was completed with histological coupes. To our knowledge, this is the first report to demonstrate the laurel effect on energy metabolism and oxidative stress.