| 三唑类衍生物对肝癌细胞株BEL-7402增殖的影响 |
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| 引用本文： | 马翠萍,石超. 三唑类衍生物对肝癌细胞株BEL-7402增殖的影响[J]. 青岛科技大学学报(自然科学版), 2009, 30(2) |
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| 作者姓名： | 马翠萍 石超 |
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| 作者单位： | 青岛科技大学,化学与分子工程学院,山东,青岛,266042;青岛科技大学,化学与分子工程学院,山东,青岛,266042 |
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| 基金项目： | 青岛科技大学博士科研启动基金 |
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| 摘 要： | 通过体外药敏性实验,对几种三唑类衍生物抗肿瘤活性进行了研究,从Cf、Db、Cc、Cg、Dc 5种三唑类化合物中筛选出Db。实验表明,Db对肝癌细胞株BEL-7402增殖有明显的抑制作用,抑制率呈浓度和时间依赖性。进一步实验证明,Db能够通过引发细胞产生自由基、线粒体膜电位下降等途径诱导细胞凋亡。
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| 关 键 词： | 三唑类衍生物 线粒体膜电位 自由基 细胞凋亡 |
Effects of Benzotriazole on Proliferation of Hepatocarcinoma BEL-7402 Cancer Cells |
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| MA Cui-ping,SHI Chao. Effects of Benzotriazole on Proliferation of Hepatocarcinoma BEL-7402 Cancer Cells[J]. Journal of Qingdao University of Science and Technology:Natutral Science Edition, 2009, 30(2) |
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| Authors: | MA Cui-ping SHI Chao |
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| Affiliation: | College of Chemistry and Molecular Engineering;Qingdao University of Science and Technology;Qingdao 266042;China |
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| Abstract: | Benzotriazole compounds have been found to show extensive biological activities.Many of them have been developed and used as fungicides,plant growth regulators and medicine.In the present study,we find five new bioactive benzotriazole derivatives Cf,Db,Cc,Cg,Dc,of which one compound Db was selected.It was demonstrated that Db could significantly inhibit proliferation of cultured hepatocarcinoma BEL-7402 cancer cells in a dose-and time-dependent manner.Treatment with Db resulted in the generation of reactive... |
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| Keywords: | benzotriazole mitochondrial membrane potential reactive oxygen species apoptosis |
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