基于细胞—计算机交互的细胞控制方法

Wiener在控制论(Cybernetics)中强调了两大类控制对象:机器与动物.半个世纪以来,机器控制领域已形成一套较为完备且先进的控制理论,而在生物控制方面,由于生物系统的特殊性和复杂性,对生命的基本组成单位-细胞的控制仍然进展缓慢.近年来,随着合成生物学技术的发展,基于细胞-计算机交互的胞外控制手段开始引起研究者...

Control Cells Based on Cell-Computer Interfacing

Wiener emphasized two major categories of control objects in cybernetics:machines and animals.In the past half century,a relatively complete and advanced control theory has been formed in the field of machine control.However,due to the particularity and complexity of biological systems,the control of cell,the basic unit of life,is still progressing slowly.In recent years,with the development of synthetic biology tools,in silico control methods based on cell-computer interfacing has drawn researchers'attention,bringing unprecedented opportunities for cell control.These methods can adapt to the particularity of biological system,take advantages of in silico control,realize automatic real-time cell control and provide a large amount of data and methods for human research on endogenous gene regulation mechanism or other activities.Based on current progress,this review summarized the biological tools and control algorithms used in cell-machine interfacing,illustrated the particularities and difficulties and pointed out the feasibility and importance to achieve intelligent cell control.