Short communication: Antiviral activity of subcritical water extract of Brassica juncea against influenza virus A/H1N1 in nonfat milk |
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| Authors: | N-K Lee J-H Lee S-M Lim KA Lee YB Kim P-S Chang H-D Paik |
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| Affiliation: | * Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 143-701, Republic of Korea;† Department of Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea;‡ Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Republic of Korea;§ Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Republic of Korea |
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| Abstract: | Subcritical water extract (SWE) of Brassica juncea was studied for antiviral effects against influenza virus A/H1N1 and for the possibility of application as a nonfat milk supplement for use as an “antiviral food.” At maximum nontoxic concentrations, SWE had higher antiviral activity against influenza virus A/H1N1 than n-hexane, ethanol, or hot water (80°C) extracts. Addition of 0.5 mg/mL of B. juncea SWE to culture medium led to 50.35% cell viability (% antiviral activity) for Madin-Darby canine kidney cells infected with influenza virus A/H1N1. Nonfat milk supplemented with 0.28 mg/mL of B. juncea SWE showed 39.62% antiviral activity against influenza virus A/H1N1. Thus, the use of B. juncea SWE as a food supplement might aid in protection from influenza viral infection. |
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| Keywords: | Brassica juncea influenza virus antiviral activity subcritical water extraction |
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