Generation of biologically active nano-aerosol by an electrospray-neutralization method |
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Authors: | Victor N Morozov |
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Affiliation: | 1. National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA;2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow Region 142290, Russia |
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Abstract: | A simple method for manufacturing biological nano-aerosols is described. It is based on gas-phase neutralization of a cloud of highly charged electrospray-generated particles or macromolecular ions with a cloud of oppositely charged electrospray products, e.g., ions of a volatile solvent. It was demonstrated that the electrosprayed products became neutralized within a few seconds, forming a stable nano-aerosol composed of single polymer molecules, nanofibers, or nano-clusters of different sizes, depending on polymer concentration, solvent, humidity, and other factors. It was also demonstrated that enzymes aerosolized by this mild technique retain their specific activity, which opens a variety of new applications for this technology. |
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