| 氟碳化合物FC-77——脂质体囊泡的制备及性能研究 |
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| 引用本文： | 王虑,刘雪峰,张强,李文放,林兆奋,王俊玲,朱君. 氟碳化合物FC-77——脂质体囊泡的制备及性能研究[J]. 有机氟工业, 2010, 0(4): 20-23,29 |
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| 作者姓名： | 王虑 刘雪峰 张强 李文放 林兆奋 王俊玲 朱君 |
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| 作者单位： | [1]上海长征医院,上海200003 [2]纳米技术及应用国家工程研究中心,上海200241 |
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| 摘 要： | 通过19F NMR、紫外可见光谱、激光粒度仪、Zeta电势和透射电子显微镜等方法研究了生理条件下(pH7.4)FC-77与脂质体囊泡的相互作用。结果表明,脂质体囊泡使得FC-77分子的紫外吸收光谱发生明显位移;FC-77使得脂质体囊泡的粒径和电势均增加。进一步的研究表明,FC-77能够引起囊泡双层膜通透性的降低。为开发FC-77的脂质体药物、增加FC-77的临床利用率提供了基础。
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| 关 键 词： | 氟碳化合物 卵磷脂囊泡 增溶 |
Preparation and Property Research of Perfluoro-Compound FC-77/Liposome Vesicles |
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| Wang Lv,Liu Xuefeng,Zhang Qiang,Li Wenfang,Lin Zhaofen,Wang Junlin,Zhu Jun. Preparation and Property Research of Perfluoro-Compound FC-77/Liposome Vesicles[J]. Organo-Fluorine Industry, 2010, 0(4): 20-23,29 |
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| Authors: | Wang Lv Liu Xuefeng Zhang Qiang Li Wenfang Lin Zhaofen Wang Junlin Zhu Jun |
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| Affiliation: | 1.Shanghai Changzheng Hospital,Shanghai 200003,China;2.National Engineering Research Center for Nanotechnology,Shanghai 200241,China) |
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| Abstract: | The FC-77-loaded liposome vesicles are prepared and characterized using19F NMR,UV-vis spectrum,dynamic light scattering and transmission electron microscopy.Furthermore,the interaction mechanism between perfluoro-compound FC-77 and liposome vesicles are investigated.The results show that FC-77 molecule can be solubilized in liposome vesicle and the UV-vis absorption bands of FC-77 are obviously changed by the liposome vesicles.On the other hand,FC-77 molecules raise the diameter and zeta potential of liposome vesicles and lower the permeability of liposome vesicles.In a word,the perfluoro-compound FC-77 can interact with liposome vesicles and be loaded by liposome vesicles,which provide the base for developing FC-77-loaded liposome and increasing clinical utility. |
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| Keywords: | fluorocarbons liposome vesicle solubilization |
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