| TRFIA螯合剂中间体2,6-二(3′-溴甲基-1′-吡唑基)-4-溴吡啶的合成、分离与表征 |
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| 引用本文： | 刘婷婷,宁志刚,赫文龙,潘利华.TRFIA螯合剂中间体2,6-二(3′-溴甲基-1′-吡唑基)-4-溴吡啶的合成、分离与表征[J].化学与生物工程,2009,26(6):40-42. |
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| 作者姓名： | 刘婷婷 宁志刚 赫文龙 潘利华 |
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| 作者单位： | 1. 长春工业大学生物工程学院,吉林,长春,130012
2. 中国科学院长春应用化学研究所国家电化学光谱分析研究中心,吉林,长春,130022 |
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| 摘 要： | 以2,6-二（3-甲基-1-H-吡唑基）-4-溴吡啶为原料,经重氮化、溴化合成了新型时间分辨荧光免疫分析（TR-FIA）双功能螯合剂中间体2,6-二（3＇-溴甲基-1＇-吡唑基）-4-溴吡啶,通过IR、GC-MS1、HNMR和元素分析等对其结构进行了确认,探讨了合成条件及反应机理。同时,通过GC-MS1、HNMR和元素分析等对第一副产物4-溴-2-（3＇-溴甲基-1＇-吡唑基）-6-（3＇-甲基-1＇-吡唑基）吡啶的结构也进行了确认,以其为原料可继续合成目标化合物,大幅提高总产率。
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| 关 键 词： | 时间分辨荧光免疫分析（TRFIA） 2 6-二（3＇-溴甲基-1＇-吡唑基）-4-溴吡啶 4-溴-2-（3＇-溴甲基-1＇-吡唑基）-6-（3＇-甲基-1＇-吡唑基）吡啶 螯合剂 |
Synthesis,Separation and Characterization of TRFIA Chelates Intermediate 4-Bromo-2,6-bis(3-(bromomethyl)-1H-pyrazol-1-yl)pyridine |
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| LIU Ting-ting,NING Zhi-gang,HE Wen-long,PAN Li-hua.Synthesis,Separation and Characterization of TRFIA Chelates Intermediate 4-Bromo-2,6-bis(3-(bromomethyl)-1H-pyrazol-1-yl)pyridine[J].Chemistry & Bioengineering,2009,26(6):40-42. |
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| Authors: | LIU Ting-ting NING Zhi-gang HE Wen-long PAN Li-hua |
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| Affiliation: | LIU Ting-ting1,NING Zhi-gang1,HE Wen-long1,PAN Li-hua2(1.Institute of Bioengineering,Changchun University of Technology,Changchun 130012,China,2.National Analytical Research Center of Electrochemistry and Spectroscopy,Changchun Institute of Applied Chemistry,Chinese Academy of Science,Changchun 130022,China) |
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| Abstract: | A new bifunctional chelate intermediate of time-resolved fluorescence immunoassay 4-bromo-2,6-bis(3-(bromomethyl)-1H-pyrazol-1-yl)pyridine was prepared from 4-bromo-2,6-bis(3-methyl-1H-pyrazol-1-yl)pyridine by diazotizing reaction and brominating reaction.The structure of the product was determined by IR,1HNMR,GC-MS and elemental analysis.The reaction conditions and reaction mechanism were also researched.At the same time,the main outgrowth 4-bromo-2-(3-(bromomethyl)-1H-pyrazol-1-yl)-6-(3-methyl-1H-pyrazol-... |
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| Keywords: | time-resolved fluorescence immunoassay(TRFIA) 4-bromo-2 6-bis(3-(bromomethyl)-1H-pyrazol-1-yl)pyridine 4-bromo-2-(3-(bromomethyl)-1H-pyrazol-1-yl)-6-(3-methyl-1H-pyrazol-1-yl)pyridine chelate |
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