铁氰化钾在有机合成中的应用

铁氰化钾因其特殊的氧化能力,在反应中表现出了其他氧化剂所不具备的氧化特性,在有机合成领域中起着重要的作用。它可促进多种反应,如:分子内和分子间的氧化偶联、胺类脱氢、C—H键氧化羟基化、Jacobson合成法、去羰基化、肟类化合物的脱肟反应等。这些反应被广泛应用于多种配体和具有生理活性的药物及天然产物的合成中。对铁氰化钾近几年来在有机合成领域中的发展状况、相关反应机理及良好的应用前景进行了概况性介绍。这其中也包括作者对该领域的一点贡献。

Application of Potassium Ferricyanide in Organic Synthesis

Because of its special oxidation capacity,potassium ferricyanide shows the oxidative characteristics that other oxidants do not have in reactions and plays an important role in organic synthesis.Various of organic reactions which could be promoted by the reagent,for example,are the intramolecular and intermolecular coupling of phenols,oxidative hydroxylation of unsaturated C—H bonds,Jacobson synthesis,decarboxylation,dehydrogenation of amines,deoximation,et al.In addition,these reactions could be widely used in the synthesis of ligands,drugs and natural products which have physiological activities.The favourable application prospect,status of development in recent years and correlative reaction mechanism of potassium ferricyanide were summarized and discussed including the contribution of the author in the field of organic synthesis for years.