卤代甘脲衍生物的合成及杀菌活性

为寻求高效且环保的新型杀菌剂,分别以2,4-(1,3-亚丙基)甘脲和2,4-(1,3-邻苄二基)甘脲为原料,通过氯代、溴代和碘代反应获得两类6种二卤代甘脲衍生物。采用菌落计数法和菌丝生成速率法测试目标衍生物对大肠杆菌、枯草杆菌、金黄色葡萄球菌、酵母菌、链球菌和放线菌等6种常见菌种的杀菌率和EC50值,结果表明卤代甘脲衍生物都具有良好的杀菌活性,且遵循碘取代甘脲>溴取代甘脲>氯取代甘脲的规律。

Synthesis and Fungicidal Activity of Halogenated Glycoluril Derivatives

To develope new fungicides with high-effective and environmental advantages,two kinds of six dihalogenated glycoluril derivatives were synthesized based on chlorination reaction,bromination reaction and iodination reaction using 2,4-(1,3-propylidene) glycoluril and 2,4-(1,3-o-benzyl) glycoluril as starting materials,respectively.Based on dihalogenated glycoluril derivatives on six common species escherichia coli,bacillus subtilis,staphylococcus aureus,saccharomyces cerevisiae,streptococcus and actinomycete,colony counting method was used for determining sterilizing rate,and mycelium formation rate method was used for obtaining the EC50 values.The target halogenated glycoluril derivatives had good fungicidal activity,followed the regularities of iodinated glycoluril,brominated glycoluril and chlorinated glycoluril.