Plasma glucagon-like peptide-1 (7-36) amide (GLP-1) response to liquid phase, solid phase, and meals of differing lipid composition |
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| Authors: | AE Brynes GS Frost CM Edwards MA Ghatei SR Bloom |
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| Affiliation: | School of Chemistry, Queen's University, Belfast, UK. |
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| Abstract: | alpha-Keto-beta-aminoacids 5a-c can be reductively aminated with the peptide sequence H2N-Leu-Val-Phe-Phe on a solid support to afford N-carboxy alkyl peptides 1a-c. The N-carboxy alkyl lysine derivative 7 was subsequently extended from the N-terminus with glutamine and histidine residues. |
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