Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy |
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Authors: | Gema Flores Keyvan Dastmalchi Shi-Biao Wu Kathleen Whalen Abdoulaye J Dabo Kurt A Reynertson Robert F Foronjy Jeanine M D′Armiento Edward J Kennelly |
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Affiliation: | 1. Department of Biological Sciences, Lehman College and the Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, USA;2. Instituto de Fermentaciones Industriales, Consejo Superior de Investigaciones Científicas (CSIC), c/Juan de la Cierva 3, 28006 Madrid, Spain;3. Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W. 168th Street, P&S 9-449, New York, NY 10032, USA |
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Abstract: | The potential therapeutic effects of Costa Rican guava (Psidium friedrichsthalianum) extracts for chronic obstructive pulmonary disease were examined. The ethyl acetate fraction displayed the highest antioxidant activity, as compared to the hexane, chloroform, and n-butanol fractions, as well as the crude extract. This fraction was evaluated for its anti-inflammatory activity response relationship against interleukin-8 (IL-8) and inhibition of matrix metalloproteinase-1 (MMP-1) expression before and after treatment with cigarette smoke. The ethyl acetate fraction exhibited inhibitory activity against IL-8 production and MMP-1 expression, showing the most potent inhibitory activities in both assays at 100 μg/mL, and nine compounds (1–9) were found. Phenolic compounds 1-O-trans-cinnamoyl-β-d-glucopyranose (2), ellagic acid (3), myricetin (4), quercitrin (7), and quercetin (9) were identified using standard compounds or literature reports from related species. Compounds 1, 5, 6, and 8 were tentatively identified as 1,5-dimethyl citrate (1), sinapic aldehyde 4-O-β-d-glucopyranose (5), 3,3′,4-tri-O-methylellagic acid-4′-O-d-glucopyranoside (6), and 1,3-O-diferuloylglycerol (8), All nine compounds are reported for the first time in Costa Rican guava. |
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Keywords: | Costa Rican guava Psidium friedrichsthalianum Antioxidants Interleukin-8 (IL-8) Matrix metalloproteinase-1 (MMP-1) Chronic obstructive pulmonary disease (COPD) |
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