| 大枣多糖与山楂乙醇提取物协同抗氧化研究 |
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| 引用本文： | 李晓梅,康文艺.大枣多糖与山楂乙醇提取物协同抗氧化研究[J].精细化工,2009(2). |
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| 作者姓名： | 李晓梅 康文艺 |
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| 作者单位： | 河南大学天然药物研究所;河南大学药学院; |
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| 基金项目： | 河南省教育厅基础研究计划(2008A360002)~~ |
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| 摘 要： | 用清除2,2′-连氨-(3-乙基苯并噻唑啉-6-磺酸)二氨盐(ABTS)自由基法,研究了大枣多糖(JDP)、山楂乙醇提取物、JDP与山楂乙醇提取物组合的复合物的协同抗氧化作用。综合运用加和法和直接比较法分析了复合物的协同作用,用响应曲面法分析讨论了单一组分及协同作用对复合物的抗氧化活性的影响。清除ABTS自由基的实验结果表明:清除氧自由基能力的大小顺序为:SC>SD>SB>DW>SE>SA;其中SC(IC50=2.51 mg/L)的抗氧化活性最强,JDP与SC和JDP与SE分别具有协同抗氧化活性。
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| 关 键 词： | 大枣多糖 山楂乙醇提取物 抗氧化 协同作用 中药现代化技术 |
Synergistic Antioxidation of Jujube Polysaccharide and Hawthorn Ethanol Extracts |
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| LI Xiao-mei,KANG Wen-yi.Synergistic Antioxidation of Jujube Polysaccharide and Hawthorn Ethanol Extracts[J].Fine Chemicals,2009(2). |
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| Authors: | LI Xiao-mei KANG Wen-yi |
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| Affiliation: | 1.Institute of Natural Products;Henan University;Kaifeng 475004;Henan;China;2.Pharmaceutical College of Henan University;China |
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| Abstract: | Independent and synergistic antioxidation of jujube polysaccharide(JDP) and Hawthorn extracts was screened by the 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid] diammonium salt(ABTS) assay.The effect of synergistic antioxidation was analyzed by three methods comprising addition methodology(AM),direct comparison methodology(DCM) and response surface methodology(RSM).Sequence of the sacvenging effect of different JDP and hawthorn ethanol extracts on ABTS freeradical was SC>SD>SB>DW>SE>SA.The antioxidation effect of SC was the strongest(IC50=2.51 mg/L).The synergistic antioxidation effects of JDP and SC,JDP and SE were obtained by ABTS assay separately. |
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| Keywords: | jujube polysaccharide hawthorn ethanol extracts antioxidation synergistic effect modernized technology of traditional Chinese medicines |
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