Effect of palm oil carotene on breast cancer tumorigenicity in nude mice |
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Authors: | Nesaretnam Kalanithi Radhakrishnan Ammu Selvaduray Kanga Rani Reimann Karin Pailoor Jayalakshmi Razak Ghazali Mahmood Mina Mustafa Dahliwal Jasbir Singh |
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Affiliation: | (1) Malaysian Palm Oil Board, Bandar Baru Bangi, 6 Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang Selangor, Malaysia;(2) International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia;(3) Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;(4) Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Malaysia;(5) Institute for Medical Research, 50588 Kuala Lumpur, Malaysia |
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Abstract: | Biological therapies are new additions to breast cancer treatment. Among biological compounds, β-carotene has been reported
to have immune modulatory effects, in particular, enhancement of natural killer cell activity and tumor necrosis factor-alpha
production by macrophages. The objective of this study was to investigate the effect of palm carotene supplementation on the
tumorigenicity of MCF-7 human breast cancer cells injected into athymic nude mice and to explore the mechanism by which palm
carotenes suppress tumorigenesis. Forty-eight 4-wk-old mice were injected with 1×106 MCF-7 cells into their mammary fat pad. The experimental group was supplemented with palm carotene whereas the control group
was not. Significant differences were observed in tumor incidence (P<0.001) and tumor surface area and metastasis to lung (P<0.005) between the two groups. Natural killer (NK) cells and B-lymphocytes in the peripheral blood of carotene-supplemented
mice were significantly increased (P<0.05 and P<0.001, respectively) compared with controls. These results suggest that palm oil carotene is able to modulate the immune
system by increasing peripheral blood NK cells and B-lymphocytes and suppress the growth of MCF-7 human breast cancer cells. |
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