Miconazole chewing gum as a drug delivery system test of release promoting additives

The release of the antifungal drug miconazole from chewing gum formulations was evaluated in vitro and in vivo. It was proven that the addition of the anionic surfactant Panodan® 165 and polyethyleneglycol 6000 increased the release of miconazole. The anionic surfactant made the chewing gum tacky. The addition of polyethyleneglycol 6000 reduced the tacky properties of the chewing gum. 4 healthy volunteers obtained therapeutically active concentrations of miconazole in saliva when they chewed gum. The salivary concentrations of miconazole were estimated, both by a reverse phase HPLC method and a plate microbioassay.