Miconazole chewing gum as a drug delivery system test of release promoting additives |
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Authors: | Morten Pedersen Margrethe R. Rassing |
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Abstract: | The release of the antifungal drug miconazole from chewing gum formulations was evaluated in vitro and in vivo. It was proven that the addition of the anionic surfactant Panodan® 165 and polyethyleneglycol 6000 increased the release of miconazole. The anionic surfactant made the chewing gum tacky. The addition of polyethyleneglycol 6000 reduced the tacky properties of the chewing gum. 4 healthy volunteers obtained therapeutically active concentrations of miconazole in saliva when they chewed gum. The salivary concentrations of miconazole were estimated, both by a reverse phase HPLC method and a plate microbioassay. |
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