Preparation,characterisation and activity of the inclusion complex of paeonol with β-cyclodextrin |
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| Authors: | Yuhsin Tsai Hsieh-Ho Tsai Chien-Pang Wu Fuu-Jen Tsai |
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| Affiliation: | 1. School of Chinese Medicine, China Medical University, Taichung, Taiwan;2. Nano-Powder and Thin Film Technology Center, Industrial Technology Research Institute, Tainan, Taiwan;3. School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan;4. Department of Medical Genetics, Pediatrics and Medical Research, China Medical University Hospital, Taichung, Taiwan;5. Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan |
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| Abstract: | The inclusion complex of β-cyclodextrin (β-CD) and paeonol (2′-hydroxy-4′-methoxyacetophenone, PAE) was synthesised and characterised by thermal gravimetric analysis (TGA) and two-dimensional rotating frame spectroscopy (2D ROESY). The antioxidant activity and tyrosinase inhibition activity were also studied. The TGA results indicated that the thermal stability of PAE was improved when it was included with β-CD. Based on the 2D ROESY analysis, an inclusion structure of the PAE–β-CD complex was proposed, in which PAE penetrated β-CD in a tilted manner due to the interaction of intermolecular hydrogen bonds between PAE and β-CD. The complex of PAE with β-CD increased the antioxidant activity and tyrosinase-inhibiting activity of PAE. |
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| Keywords: | Paeonol β-Cyclodextrin ROESY Antioxidant activity Tyrosinase inhibition |
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