Cajanuslactone,a new coumarin with anti-bacterial activity from pigeon pea [Cajanus cajan (L.) Millsp.] leaves |
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| Authors: | Yu Kong Yu-Jie Fu Yuan-Gang Zu Fang-Rong Chang Yung-Husan Chen Xiao-Lei Liu Johannes Stelten Hans-Martin Schiebel |
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| Affiliation: | 1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China;2. Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China;3. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan;4. Department of Chemistry, University of Bremen, Leobener Strasse NW 2C, D-28359 Bremen, Germany;5. Institute of Organic Chemistry, Technical University of Braunschweig, Hagenring 30, D38106 Braunschweig, Germany |
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| Abstract: | The bioassay-guided fractionation of the CHCl3 extract from pigeon pea leaves led to the isolation of a new natural coumarin, named as cajanuslactone (1), together with two known phytoalexins, pinostrobin (2) and cajaninstilbene acid (3). The structure of 1 was elucidated by interpreting spectroscopic data of UV, IR, MS, 1D and 2D NMR. It was determined as 7-hydroxy-5-O-methyl-8-(3-methyl-2-butylene)-4-phenyl-9,10-dihydro-benzopyran-2-one. The anti-bacterial activity against three Gram-positive microorganisms was evaluated in vitro. It was found the new compound cajanuslactone possessed good anti-bacterial activity against Staphylococcus aureus (ATCC 6538), and the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were 0.031 and 0.125 mg/ml, respectively. The result indicated that the leaf part of pigeon pea is an excellent source of natural anti-bacterial materials. Moreover, cajanuslactone is a potential anti-bacterial agent against Gram-positive microorganisms. |
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| Keywords: | Cajanus cajan (L ) Millsp Coumarin Cajanuslactone Anti-bacterial activity |
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