Antioxidant and antiproliferative activities of mango (Mangifera indica L.) flesh and peel |
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Authors: | Hana Kim Jeong Yong Moon Hyeonji Kim Dong-Sun Lee Moonjae Cho Hyung-Kyoon Choi Young Suk Kim Ashik Mosaddik Somi Kim Cho |
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Affiliation: | 1. Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea;2. Department of Medicine, Medical School, Jeju National University, Jeju 690-756, Republic of Korea;3. College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea;4. Department of Food Science and Technology, Ewha Womans University, Seoul 120-750, Republic of Korea;5. The Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University, Jeju 690-756, Republic of Korea;6. Subtropical Horticulture Research Institute, Jeju National University, Jeju 690-756, Republic of Korea |
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Abstract: | The antioxidant and antiproliferative properties of flesh and peel of mango (Mangifera indica L.) were investigated. The cytoprotective effect of mango flesh and peel extracts on oxidative damage induced by H2O2 in a human hepatoma cell line, HepG2, were determined, and the underlying mechanism was examined by a single-cell electrophoresis assay (comet assay). Treatment of HepG2 cell with mango peel extract prior to oxidative stress was found to inhibit DNA damage. The free radical scavenging activities of mango flesh and peel extracts were evaluated by electron spin resonance (ESR). The mango peel extract exhibited stronger free radical scavenging ability on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and alkyl radicals than mango flesh extract, regardless of ripeness. Similarly, peel extract exhibited significant antiproliferative effect against all tested cancer cell lines, compared to that of flesh extract, in a dose-dependent manner. The result also showed that the antiproliferative activity of mango flesh and peel extracts correlated with their phenolic and flavonoid contents. Thus, mango peel, a major by-product obtained during the processing of mango product, exhibited good antioxidant activity and may serve as a potential source of phenolics with anticancer activity. |
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Keywords: | Antioxidant activity Antiproliferative activity Electron spin resonance (ESR) Free radical scavenging activity Mango flesh Mango peel |
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