Flavonoids from Rabdosia rubescens exert anti-inflammatory and growth inhibitory effect against human leukemia HL-60 cells |
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Authors: | Naisheng Bai Kan He Zhu Zhou Ching-Shu Lai Li Zhang Zheng Quan Xi Shao Min-Hsiung Pan Chi-Tang Ho |
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Affiliation: | 1. Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA;2. Naturex, Inc., 375 Huyler Road, South Hackensack, NJ 07606, USA;3. College of Pharmacy, Fudan University, Shanghai, 200032, People’s Republic of China;4. Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan |
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Abstract: | Eight flavonoids, 5,8,4′-trihydroxy-6,7,3′-trimethoxyflavone (1), 5,4′-dihydroxy-6,7,8,3′-tetramethoxyflavone (2), nodifloretin (3), pedalitin, (4), penduletin (5), cirsiliol (6), luteolin (7), and quercetin (8), were isolated from the aerial parts of Rabdosia rubescens. Structures were established on the basis of 1D and 2D NMR and HRMS data. All flavonoids were tested for cytotoxicity in a small panel of cancer cell lines (Hep G2, COLO 205, MCF-7, and HL-60) and anti-inflammatory activity in LPS-treated RAW264.7 macrophage. Among them, compounds (1) and (4) were modestly active for inhibiting nitrite production in macrophage. Compound (2) was demonstrated to be selectively active against HL-60 cells with an IC50 of 7.55 μM. This value is comparable to the IC50 4.64 μM of doxorubicin, the positive control used in this investigation. |
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Keywords: | Rabdosia rubescens (Hemsl.) Flavonoids, human cancer cell lines (Hep G2, COLO 205, MCF-7, and HL-60) Anti-inflammatory |
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