Phenolic profiles,antioxidant activity and in vitro antiviral properties of apple pomace |
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Authors: | Belé n Suá rez,Á ngel L. Á lvarez,Yolanda Diñ eiro Garcí a,Gloria del Barrio,Anna Picinelli Lobo,Francisco Parra |
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Affiliation: | 1. Área de Tecnología de los Alimentos, Servicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), 33300 Villaviciosa, Asturias, Spain;2. Departamento de Microbiología y Virología, Facultad de Biología, Universidad de La Habana, 10400 La Habana, Cuba;3. Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain |
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Abstract: | Methanolic and acetonic extracts of apple pomace were evaluated for phenolic profiles, antioxidant properties and antiviral effect against herpes simplex virus type 1 (HSV-1) and 2 (HSV-2). Acetone extraction yielded the higher amounts of phenolic compounds. The extraction method influenced the phenolic composition although antioxidant activity correlated weakly with phenols concentration. Among the polyphenols analysed, quercetin glycosides were the most important family, followed by dihydrochalcones. Apple pomace extracts were able to inhibit both HSV-1 and HSV-2 replication in Vero cells by more than 50%, at non-cytotoxic concentrations. Selectivity indexes (SI) ranged from 9.5 to 12.2. |
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Keywords: | Apple pomace Antioxidant Antiviral Herpes |
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