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Taurine alleviates dyslipidemia and liver damage induced by a high-fat/cholesterol-dietary habit |
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| Authors: | Shun-Fa Yang Bor-Show Tzang Kuo-Tai Yang Yuan-Chao Hsiao Yuan-Yen Chang Chi-Ho Chan Shih-Guei Fu Yi-Chen Chen |
| Affiliation: | 1. Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan;2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan;3. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan;4. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan;5. Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan;6. Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan;g School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan;h Department of Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan;i Department of Applied Life Science, Cha-Nan University of Pharmacy and Science, Tainan County 700, Taiwan;j Department of Nutrition, Chung Shan Medical University Hospital, Taichung 402, Taiwan |
| Abstract: | Eight male hamsters per group were assigned randomly to one of the following diets: chow diet (Control); high-fat/cholesterol diet (HFCD); HFCD supplemented with 1% Tau (HFCD/1% Tau); HFCD supplemented with 2% Tau (HFCD/2% Tau). Tau supplementation improved (P < 0.05) serum lipids and cholesterol profile in the high-fat/cholesterol-dietary hamsters. Although hepatic cholesterol/triacylglycerol in the high-fat/cholesterol-dietary hamsters were not (P > 0.05) changed by Tau supplementation, faecal cholesterol and bile acid outputs were increased (P < 0.05). Two percent Tau supplementation unregulated (P < 0.05) HMG-CoA reductase and cholesterol 7-α hydroxylase (CYP7A1) expressions in the high-fat/cholesterol-dietary hamsters. Besides, Tau supplementation also increased (P < 0.05) LDL receptor mRNA expressions in high-fat/cholesterol-dietary hamsters. Tau supplementation also reduced serum GPT and GOT values and C-reactive protein (CRP) levels in the high-fat/cholesterol-dietary hamsters. Results clearly indicated that Tau could alleviate blood lipids and hepatic damage induced by a high-fat/cholesterol-dietary diet. |
| Keywords: | Taurine Serum lipids Hepatic lipids Faecal lipids and bile acid HMG-CoA reductase CYP7A1 LDL receptor GPT GOT Hepatic C-reactive protein |
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