Isolation of red wine components with anti-adhesion and anti-biofilm activity against Streptococcus mutans |
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| Authors: | Maria Daglia Monica Stauder Adele Papetti Caterina Signoretto Giovanni Giusto Pietro Canepari Carla Pruzzo Gabriella Gazzani |
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| Affiliation: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pavia University, Via Taramelli 12, 27100 Pavia, Italy;2. Istituto di Microbiologia e Scienze Biomediche, Marche Polytechnic University, 60020 Ancona, Italy;3. Dipartimento di Patologia, Sezione di Microbiologia, Verona University, Strada Le Grazie 8, 37134 Verona, Italy;4. DIBIO, Genova University, Corso Europa 26, 16123 Genova, Italy |
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| Abstract: | Red wine is a widely consumed beverage with multiple beneficial effects on human health. In the present paper, the anticaries properties of red wine were studied in vitro and ex vivo. Our in vitro findings shows that dealcoholised red wine, besides exerting antibacterial activity, strongly interferes with Streptococcus mutans adhesion to saliva-coated hydroxyapatite (sHA) beads, promotes its detachment from sHA, and powerfully inhibits in vitro biofilm formation. The main components responsible for such activities were found to be proanthocyanidins. The ability of red wine to inhibit ex vivoS. mutans biofilm formation on the occlusal surface of natural human teeth also was demonstrated. |
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| Keywords: | Red wine Streptococcus mutans Caries Adherence Biofilm |
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