| 稀土乙酸8-羟基喹啉三元配合物/羟基磷灰石的纳米有机/无机主客体组装复合抗菌生物材料 |
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| 引用本文： | 王春艳,于红,李尚宇,范国镇,王润伟.稀土乙酸8-羟基喹啉三元配合物/羟基磷灰石的纳米有机/无机主客体组装复合抗菌生物材料[J].复合材料学报,2008,25(6):107-110. |
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| 作者姓名： | 王春艳 于红 李尚宇 范国镇 王润伟 |
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| 作者单位： | 1.吉林大学 化学学院, 长春 130012;2.吉林大学 公共卫生学院, 长春 130021;3.吉林省肿瘤医院 血液科, 长春 130012;4. 吉林大学 麦克德尔米德实验室, 长春130012;5.长春市产品质量监督检验院, 长春 130012;6.中国人民银行, 长春 130051 |
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| 基金项目： | 国家自然科学基金（29873017； 20741001） |
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| 摘 要： | 采用湿法原位合成了Tb、Y、Gd 3种稀土乙酸8-羟基喹啉三元配合物与羟基磷灰石的纳米有机/无机主客体组装复合材料。通过扫描电子显微镜、X射线粉末衍射、红外光谱对样品进行结构分析测定；采用最低抑菌浓度(MIC)和最低杀菌浓度(MBC)实验来检测其抗菌能力。结果表明， 3种复合材料纳米晶平均粒径为50～60 nm，皆对金黄葡萄球菌和大肠杆菌具有较高的抗菌作用，并对金黄葡萄球菌的抑制作用强于大肠杆菌。经过对3种复合材料抗菌作用的比较得出抗菌能力的次序为： Tb-HQ/HAP < Y-HQ/HAP < Gd-HQ/HAP。
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| 关 键 词： | 羟基磷灰石 8-羟基喹啉 有机/无机复合材料 抗菌活性 湿法合成 最低抑菌浓度 最低杀菌浓度 |
| 收稿时间： | 2008-03-06 |
| 修稿时间： | 2008-07-25 |
Antibacterial composites of nano organic/inorganic: Ternary solid composites of rare earth with acetic acid and 8-hydroxyquinoline/hydroxyapatite |
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| WANG Chunyan,YU Hong,LI Shangyu,FAN Guozhen,WANG Runwei.Antibacterial composites of nano organic/inorganic: Ternary solid composites of rare earth with acetic acid and 8-hydroxyquinoline/hydroxyapatite[J].Acta Materiae Compositae Sinica,2008,25(6):107-110. |
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| Authors: | WANG Chunyan YU Hong LI Shangyu FAN Guozhen WANG Runwei |
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| Affiliation: | 1. College of Chemistry, Jilin University, Changchun 130012, China;2. School of Public Health, Jilin University, Changchun 130021, China;3.Department of Hematology, Tumor Hospital of Jilin Province, Changchun 130012, China;4. Alan G. MacDiarmid Institute, Jilin University, Changchun 130012, China;5. Changchun Department for Product Quality Supervision and Testing, Changchun 130012, China;6. The People's Bank of China, Changchun 130051, China |
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| Abstract: | The rare earth (RE: Gd, Y and Tb) complexes of 8-hydroxyquinoline (8-HQ) were synthesized. The organic/inorganic hybrid composites，RE-HQ/hydroxyapatite(HAP) were directly prepared via the wet methods. The composites were characterized by means of SEM，XRD and IR. At the same time， the antibacterial activities of all the complexes were tested by using minimum inhibitory concentration (MIC)and minimum bactericidal concentration(MBC). The results show that the three composites are 50 nm～60 nm in average size and exhibit stronger acteriostatic activities against Staphylococcus aureus ( S. aureus) and Escherichia coli (E. coli). They all show higher antibacterial activity against S. aureus than against E. coli. The antibacterial efficacies of the three composites are increased in the order： Tb-HQ/HAP < Y-HQ/HAP
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| Keywords: | hydroxyapatite 8-hydroxyquinoline organic/inorganic composites antibacterial activity wet method MIC MBC |
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