18F-NaF注射液的制备及新西兰兔骨折显像

由外伤或肿瘤骨转移造成的隐匿性骨折和愈合情况的准确诊断对制定合适的治疗方案具有非常重要的意义。为考查¹⁸F-NaF PET显像用于骨折诊断的诊断效能，本研究制备了¹⁸F-NaF注射液，并对其进行了质量控制和稳定性研究，然后建立新西兰兔骨折动物模型，模型建立约2周后进行了¹⁸F-NaF PET显像和⁹⁹Tc^m-亚甲基二磷酸盐（⁹⁹Tc^m-MDP）SPECT显像的自身对照实验，并对显像效果进行了比较。结果表明：¹⁸F-NaF的产量大于37 GBq，各项检验结果均符合质控要求，40 ℃下放置8 h和30 ℃下放置10 h所有检验结果均无明显变化；¹⁸F-NaF PET和⁹⁹Tc^m-MDP SPECT两种显像方式均可见全身骨骼，骨折部位呈明显放射性浓聚，但¹⁸F-NaF给药后30 min即可进行PET显像，骨折部位显示更为清晰，骨折部位与对侧正常骨骼的放射性摄取比（T/NT）明显高于⁹⁹Tc^m-MDP，而⁹⁹Tc^m-MDP需在给药后2 h才能进行SPECT显像。本研究表明¹⁸F-NaF PET对骨折的显像性能优于⁹⁹Tc^m-MDP，可明显提高检查流通量和诊断效能。

Preparation and New Zealand Rabbit Fracture Imaging of18F-NaF Injection

The accurate diagnosis of the minute fractures and healing caused by trauma or tumor bone metastasis is very important for the development of appropriate treatment. In order to investigate the efficiency of¹⁸F-NaF PET imaging for fracture diagnosis,¹⁸F-NaF injection was prepared, and the quality control and stability were studied. Self-controlled study between¹⁸F-NaF PET imaging and⁹⁹Tc^m-MDP SPECT imaging after two weeks of the establishment of New Zealand rabbit fracture model was carried out. The results show that the production of¹⁸F-NaF is more than 37 GBq, all of the test results conform to the requirements of the quality control, and the test results are no significant changes under the conditions of 40 ℃ for 8 h and 30 ℃ for 10 h. The results of imaging show that the whole body skeleton is visible in both of⁹⁹Tc^m-MDP SPECT and¹⁸F-NaF PET imaging, and high radioactive uptakes can be detected in fracture position. But PET imaging can be performed after¹⁸F-NaF injection for 30 min, and fracture is more clearly displayed than SPECT imaging, while SPECT imaging can be performed after⁹⁹Tc^m-MDP injection for 2 h. The radioactive uptake ratio (T/NT) between the fractured and the contralateral normal bones of¹⁸F-NaF PET imaging is significantly higher than that of⁹⁹Tc^m-MDP imaging. This study indicates that¹⁸F-NaF PET is superior to⁹⁹Tc^m-MDP SPECT for fracture imaging.