多糖化学修饰的方法及其对抗肿瘤活性影响的研究进展

多糖是一种重要的生物大分子物质,具有多种生物活性。多糖的生物活性与本身的结构有着直接联系。因此,对多糖结构进行修饰,选择合适的修饰方法成为研究多糖的一个重要方向。本文主要综述了多糖的化学修饰方法及化学修饰对多糖抗肿瘤活性的影响,包括多糖的硫酸化修饰、羧甲基化修饰、酸化修饰、乙酰修饰等,并对多糖结构修饰的应用前景进行展望,以期为多糖化学修饰的深入研究与探索及糖类产品的开发与利用提供参考。

Research progress on chemical modification of polysaccharide and its effect on anti-tumor activity

Polysaccharide is an important biological macromolecular substance with many biological activities. The biological activities of polysaccharides are directly related to their own structures. Therefore, it is an important direction to modify the structure of polysaccharides and select appropriate modification methods. This article mainly reviewed the chemical modification methods of polysaccharides and the effects of chemical modification on the anti-tumor activity of polysaccharides, including sulfation modification, carboxymethylation modification, acidification modification, acetyl modification and so on. The application prospect of polysaccharide structure modification was prospected, so as to provide references for the further research and exploration of chemical modification of polysaccharides and the development and utilization of carbohydrate products.