Production of monocyte chemoattractant protein 1 in tuberculosis patients |
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| Authors: | Y Lin J Gong M Zhang W Xue PF Barnes |
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| Affiliation: | Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA. |
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| Abstract: | To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response to Mycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14+ blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+ monocytes from healthy tuberculin reactors. MCP-1 production in lymph nodes from tuberculosis patients was also markedly increased. These findings suggest that MCP-1 can contribute to the antimycobacterial inflammatory response by attracting monocytes and T lymphocytes. |
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