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| 维库溴铵的合成工艺改进 | |
| 引用本文： | 蒋虹,顾菲,屠树江,冯友建.维库溴铵的合成工艺改进[J].化学试剂,2009,31(7). |
| 作者姓名： | 蒋虹 顾菲 屠树江 冯友建 |
| 作者单位： | 1. 徐州师范大学,江苏省药用植物生物技术重点实验室 2. 徐州师范大学,化学化工学院,江苏,徐州,221116 3. 徐州师范大学,江苏省药用植物生物技术重点实验室;徐州师范大学,化学化工学院,江苏,徐州,221116 |
| 基金项目： | 徐州市科技局自然科学基金，江苏省大型科学仪器设备共享服务平台理事会资助项目，徐州师范大学自然科学研究基金 |
| 摘 要： | 以表雄酮为原料经磺酸酯化、消去、酯化、氧化、开环、还原、乙酰化,最后和溴甲烷成盐等8步反应合成维库溴铵,操作简捷、条件温和、成本低,适合工业化生产,产品结构经红外光谱、核磁共振谱、质谱确证,总收率19.6%. |
| 关 键 词： | 维库溴铵 肌松药 非去极化 合成 |
Improved synthesis of vecuronium bromide |
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| JIANG Hong,GU Fei,TU Shu-jiang,FENG You-jian.Improved synthesis of vecuronium bromide[J].Chemical Reagents,2009,31(7). | |
| Authors: | JIANG Hong GU Fei TU Shu-jiang FENG You-jian |
| Affiliation: | Xuzhou Normal University;a.Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu;b.College of Chemistry and Chemical Engineering;Xuzhou 221116;China |
| Abstract: | Vecuronium bromide was synthesized from epiandrosterone through esterification,elimination,oxidation,ring opening,reduction,and acetylation,followed by reaction with bromomethane.This cost-saving and simplified method can be used in the commercial scale manufacture.The structure of this product was elucidated by IR,1HNMR,13CNMR,DEPT and MS,with an overall product yield reaching 19.6%. |
| Keywords: | vecuronium bromide muscle relaxants non depolarizing synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |