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班布特罗的合成工艺改进
引用本文:张雪利,洪伟良,刘剑洪,张培新,罗仲宽,周晓明. 班布特罗的合成工艺改进[J]. 深圳大学学报(理工版), 2005, 22(3): 269-271
作者姓名:张雪利  洪伟良  刘剑洪  张培新  罗仲宽  周晓明
作者单位:深圳大学师范学院,深圳,518060
基金项目:国家自然科学基金资助项目(29973059),广东省自然科学基金资助项目(001232)
摘    要:针对目前国内班布特罗合成收率较低的情况,提出一条新的合成路线.以3,5二羟基苯乙酮为起始原料,经酯化→溴代→胺化→还原4步反应合成了班布特罗,各步反应简单,条件温和,总收率60.80%,是迄今为止成本最低的工艺之一,为工业生产提供了较佳的合成路线.

关 键 词:班布特罗  溴代  胺化  β2受体激动剂  合成工艺
文章编号:1000-2618(2005)03-0269-03
收稿时间:2004-12-30
修稿时间:2004-12-30

Improvement of synthesis process for Bambutarol
ZHANG Xue-li,HONG Wei-liang,LIU Jian-hong,ZHANG Pei-xin,LUO Zhong-kuan,ZHOU Xiao-ming. Improvement of synthesis process for Bambutarol[J]. Journal of Shenzhen University(Science &engineering), 2005, 22(3): 269-271
Authors:ZHANG Xue-li  HONG Wei-liang  LIU Jian-hong  ZHANG Pei-xin  LUO Zhong-kuan  ZHOU Xiao-ming
Abstract:To improve the synthesis of Bambuterol hydrochloride, Bambuterol hydrochloride was synthesized from 3,5-dihydroxyacetophenone via four steps, esterification, bromination, amination and reduction. The overall yield of 60.80% was two times higher than that of reported previously. The reaction conditions were mild and the processes were straight forward. A better industrial way for synthesis of Bambuterol hydrochloride is obtained.
Keywords:
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