| 班布特罗的合成工艺改进 |
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| 引用本文： | 张雪利,洪伟良,刘剑洪,张培新,罗仲宽,周晓明. 班布特罗的合成工艺改进[J]. 深圳大学学报(理工版), 2005, 22(3): 269-271 |
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| 作者姓名： | 张雪利 洪伟良 刘剑洪 张培新 罗仲宽 周晓明 |
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| 作者单位： | 深圳大学师范学院,深圳,518060 |
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| 基金项目： | 国家自然科学基金资助项目(29973059)，广东省自然科学基金资助项目(001232) |
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| 摘 要： | 针对目前国内班布特罗合成收率较低的情况,提出一条新的合成路线.以3,5二羟基苯乙酮为起始原料,经酯化→溴代→胺化→还原4步反应合成了班布特罗,各步反应简单,条件温和,总收率60.80%,是迄今为止成本最低的工艺之一,为工业生产提供了较佳的合成路线.
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| 关 键 词： | 班布特罗 溴代 胺化 β2受体激动剂 合成工艺 |
| 文章编号： | 1000-2618(2005)03-0269-03 |
| 收稿时间： | 2004-12-30 |
| 修稿时间： | 2004-12-30 |
Improvement of synthesis process for Bambutarol |
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| ZHANG Xue-li,HONG Wei-liang,LIU Jian-hong,ZHANG Pei-xin,LUO Zhong-kuan,ZHOU Xiao-ming. Improvement of synthesis process for Bambutarol[J]. Journal of Shenzhen University(Science &engineering), 2005, 22(3): 269-271 |
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| Authors: | ZHANG Xue-li HONG Wei-liang LIU Jian-hong ZHANG Pei-xin LUO Zhong-kuan ZHOU Xiao-ming |
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| Abstract: | To improve the synthesis of Bambuterol hydrochloride, Bambuterol hydrochloride was synthesized from 3,5-dihydroxyacetophenone via four steps, esterification, bromination, amination and reduction. The overall yield of 60.80% was two times higher than that of reported previously. The reaction conditions were mild and the processes were straight forward. A better industrial way for synthesis of Bambuterol hydrochloride is obtained. |
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