MCC/MOFs抗菌复合材料的制备及表征

采用原位沉积法将两种金属有机框架化合物（Metal-Organic Frameworks，MOFs）MOF-5和1，3，5-均苯三甲酸铜（Ⅱ）（HKUST-1）负载在微晶纤维素（MCC）上，制备出MCC/MOF-5和MCC/HKUST-1二元复合材料以及MCC/MOF-5/HKUST-1和MCC/HKUST- 1/MOF-5三元复合材料；分别采用傅里叶变换红外光谱仪（FT-IR）、X射线衍射仪（XRD）及扫描电子显微镜（SEM）分析复合材料的化学组成和微观形貌；以大肠杆菌（Escherichia coli， E-coli）为测试菌种，通过测定抑菌圈直径检测复合材料的抗菌性能。结果表明，实验成功制备出了表面覆盖有立方体结构的MOF-5和棒状结构的HKUST-1的二元和三元复合材料；由于金属离子的协同抗菌作用，三元复合材料较二元复合材料对大肠杆菌具有更优异的抗菌性能；由于Zn²⁺的抗菌能力大于Cu²⁺，MCC/HKUST-1/MOF-5的抗菌效果较MCC/MOF-5/HKUST-1好。

Preparation and Characterization of MCC/MOFs Antibacterial Composites

Binary composites (MCC/MOF-5 and MCC/HKUST-1) and ternary composites (MCC/MOF-5/HKUST-1 and MCC/HKUST-1/MOF-5) were prepared by in-situ deposition of metal-organic frameworks (MOF-5 and HKUST-1) onto the surface of microcrystalline cellulose (MCC). FT-IR and XRD were used to characterize the chemical structures of the composites. The morphologies of the composites were observed by SEM. Escherichia coli (E. coli) was used as a test strain to evaluate the antibacterial ability by measuring the diameter of the inhibition zone. The results showed that the binary and ternary composites were successfully prepared. MOF-5 and HKUST-1 on the surface of MCC exhibited cubic and rod-like shape respectively. Due to the synergistic antibacterial effect of metal ions, the ternary composites had better antibacterial properties against E. coli than the binary composites. The antibacterial effect of MCC/HKUST 1/MOF-5 was better than that of MCC/MOF-5/HKUST-1 as the antibacterial capacity of Zn²⁺ was greater than Cu²⁺.