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Nosocomial diarrhoea in the elderly due to enterotoxigenic Clostridium perfringens
Authors:A Wada  Y Masuda  M Fukayama  T Hatakeyama  Y Yanagawa  H Watanabe  T Inamatsu
Affiliation:Institute of Immunology and Transfusion Medicine, University of Lübeck School of Medicine, Germany.
Abstract:Zinc is an important trace element for immune function. Here, we show that zinc addition in a serum- and lipopolysaccharide-free cell culture system leads to significantly enhanced levels of interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) and to expression of the corresponding mRNA in human peripheral blood mononuclear cells (PBMC). Structurally related divalent cations like cobalt, nickel, and mercury also partially increase monokine secretion but to a much lower and thus insignificant extent. They fail to induce mRNA of TNF-alpha after 3 h of culture. Therefore, monokine induction is a zinc-specific effect influenced by the physicochemical properties of the ion. Confirmation of the unique significance of zinc for immune function provides a better understanding of the mechanisms of specific zinc-mediated immune modulation.
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