| Affiliation: | 1. Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR 7258, Institut Paoli Calmette, Aix-Marseille Université UM 105, Inserm, U1068, Faculté de Pharmacie, Marseille, France;2. Faculté de Médecine, Aix-Marseille Université, IRBA, TMCD2 UMR-MD1, Marseille, France;3. Aix-Marseille Université, INSERM 1263, INRA1260, C2VN, Marseille, France;4. YELEN, 10 Bd. Tempête, Ensues la Redonne, France;5. Laboratoire de Mutagénèse Environnementale, Aix-Marseille Université, CNRS, IRD, IMBE UMR 7263, Marseille, France;6. Department of Chemistry, Emory University, Atlanta, GA, USA |
| Abstract: | The emergence of multidrug‐resistant bacteria and pathogens has created an urgent need for the development of new antibiotics. Herein we report our investigations into the broad‐spectrum activity of an easily prepared water‐soluble polyaminosterol compound, namely claramine A1, against both drug‐sensitive and drug‐resistant Gram‐negative and Gram‐positive bacterial strains. We also report its peculiar mechanism of action, which differs from that of all the other well‐known classes of antibiotics, toward Gram‐negative and Gram‐positive bacteria. Given their low cytotoxicity, this class of compounds based on claramine A1 could constitute an effective response to combat the emergence of multidrug‐resistant bacteria and nosocomial diseases. |
