Affiliation: | 1. Oncology, IMED Biotech Unit, AstraZeneca, Boston, MA, USA;2. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Boston, MA, USA;3. Discovery Sciences, IMED Biotech Unit, AstraZeneca Pharmaceuticals LP, Macclesfield, UK;4. Pharmaron Beijing Co. Ltd., Beijing, P.R. China;5. Discovery Sciences, IMED Biotech Unit, AstraZeneca Pharmaceuticals LP, Cambridge, UK |