| 夏天无总碱对血小板内cAMP、cGMP含量的影响 |
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| 引用本文： | 刘忞,冯高闳,蔡锡麟. 夏天无总碱对血小板内cAMP、cGMP含量的影响[J]. 核技术, 1990, 0(1) |
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| 作者姓名： | 刘忞 冯高闳 蔡锡麟 |
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| 作者单位： | 江西医学院(刘忞，冯高闳)，江西医学院(蔡锡麟) |
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| 摘 要： | 夏天无总碱(COAMTA)系从伏生紫堇之块茎中分离出的有效成分。动物实验表明,COAMTA具有明显抑制血小板聚集、抑制血栓形成等作用。本文观察了COAMTA对家兔血小板内cAMP和cGMP含量的影响。结果0.08—0.16mg/ml PRP的COAMTA可明显提高血小板内cAMP含量;剂量为0.16mg/ml PRP还可使cGMP含量升高,但cAMP/cGMP的比值增加更为明显,提示COAMTA主要是通过影响cAMP含量而发挥抑制血小板功能的作用。
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| 关 键 词： | 夏天无 环磷酸腺苷 环磷酸鸟苷 富含血小板血浆 |
Effects of Corydalis amabilis Migo total alkaloids on platelet cyclic AMP and cyclic QMP |
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| Liu Min Feng Gaohong Cai Xilin. Effects of Corydalis amabilis Migo total alkaloids on platelet cyclic AMP and cyclic QMP[J]. Nuclear Techniques, 1990, 0(1) |
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| Authors: | Liu Min Feng Gaohong Cai Xilin |
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| Affiliation: | Jiangxi Medical College |
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| Abstract: | Corydalis amabilis Migo total alkaloids (COAMTA), isolated from the root of Co-rydalis decumbens (Thunb) Pers, possessed inhibitory action on ADP-induced blood platelet aggregation and the formation of thrombus in animal experiments. Its effects on the platelet cyclic AMP and cyclic GMP in incubated rabbit platelet were measured by radioimmunoassay.cAMP was significantly elevated when COAMTA was given 0.08-0.16mg/ml PRP. In concentration up to 0,16 mg/ml PRP, COAMTA elevated cGMP, but the ratio value of cAMP/cGMP was much higher than that of control group. These results suggest that the anti-platelet activity of COAMTA were mediated through elevation of cAMP levels. |
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| Keywords: | Corydalis amabilis Migo Cyclic AMP Cyclic GMP Plateletrich plasma |
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