首页 | 本学科首页   官方微博 | 高级检索  
     


Ion Channels in Multiple Myeloma: Pathogenic Role and Therapeutic Perspectives
Authors:Ilaria Saltarella,Concetta Altamura,Aurelia Lamanuzzi,Benedetta Apollonio,Angelo Vacca,Maria Antonia Frassanito,Jean-Franç  ois Desaphy
Abstract:Ion channels are pore-forming proteins that allow ions to flow across plasma membranes and intracellular organelles in both excitable and non-excitable cells. They are involved in the regulation of several biological processes (i.e., proliferation, cell volume and shape, differentiation, migration, and apoptosis). Recently, the aberrant expression of ion channels has emerged as an important step of malignant transformation, tumor progression, and drug resistance, leading to the idea of “onco-channelopathy”. Here, we review the contribution of ion channels and transporters in multiple myeloma (MM), a hematological neoplasia characterized by the expansion of tumor plasma cells (MM cells) in the bone marrow (BM). Deregulation of ion channels sustains MM progression by modulating intracellular pathways that promote MM cells’ survival, proliferation, and drug resistance. Finally, we focus on the promising role of ion channels as therapeutic targets for the treatment of MM patients in a combination strategy with currently used anti-MM drugs to improve their cytotoxic activity and reduce adverse effects.
Keywords:ion channels   multiple myeloma   drug resistance   therapeutic strategies
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号