A new device for coating single particles under controlled conditions |
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Authors: | Daniel Strö m,Staffan Folestad,Thomas Laurell,Anders Rasmuson |
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Affiliation: | a Department of Chemical Engineering Design, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden b Pharmaceutical and Analytical R&D, AstraZeneca AB Mölndal, SE-431 83 Mölndal, Sweden c Department of Electrical Measurements, Lund Institute of Technology, SE-221 00 Lund, Sweden |
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Abstract: | A new device for coating a single levitated particle in a controllable environment is designed and tested. This enables fluidized bed processing to be simulated experimentally on a single-particle level. The device consists of a coating chamber, which contains a capillary tube for levitating the particle, a micro-dispenser for producing discrete drops of controlled size and velocity and a device for supplying gas with specified temperature and humidity. The coating chamber consists of two parts, a confined space where the particle is levitated and a droplet insertion cone where the coating solution is injected into the particle suspending gas flow. A capillary with a well-defined diameter connects the droplet insertion cone and the area where the particle is levitated. The device is equipped with a piezo-actuated flow-through micro-dispenser that has the ability to produce discrete droplets with high reproducibility in terms of droplet size and velocity. The gas required for the coating process is taken from a gas container where the water content is analysed and kept at a minimum. A liquid flow is then introduced into the gas flow at a well-defined flow rate, mixed and evaporated in a three-way mixing vault. The humidified gas flow is then split into two separate flows; a suspending gas flow and a protecting gas flow for the inside of the coating chamber. The device is equipped with a high-speed video camera for monitoring both droplet production and droplet impact. Temperatures and flow rates throughout the device are measured and logged. Preliminary results show the influence of solvent, gas quality and coating procedure on the quality of the coating. |
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Keywords: | Particle Fluidization Drying Coating Wurster |
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