去除包衣方法对腺苷钴胺片含量的影响

为确定何种去除包衣方法对腺苷钴胺片含量测定影响最小,通过高效液相色谱法测定了经洗片、刮片、糖衣片、素片等不同的前处理后腺苷钴胺片的含量。结果表明,各种去除包衣的方法均不同程度影响着测定结果,与素片含量结果相比,洗片方式得到的含量结果最接近。刮片方式得到的片重较小,标示量较低;直接法测量糖衣片得到的结果中单位浓度不稳定,不能准确表示标示量结果。因此,洗片方式对腺苷钴胺片含量影响最小,测定腺苷钴胺片含量采用洗片的方式去除包衣效果最佳。

Effect of Coating Removal Methods on Content of Cobamamide Tablets

In order to confirm which coating removal method has minimal effect on determination of the contents of cobamamide tablets. The content of washing cobamamide tablets ,which was carried out different pretreatment-process including scraping, coated sugar, uncoated tablets were determined by high performance liquid chromatography.The results showed that various coating removal methods influnced the measurement results of the content,compared with the uncoated tablets, the result by washing tablets inprocessing weight was smaller and the labeled was the most close amount was lower,the concentration of sugar coated tablets was not stable by direct method, which couldn＇t representation accurately the labeled amount. Therefore, the effect of washing tablets processing on the content of cobamamide tablets were minimum.The effect of coating removaling by washing tablets in the determination of the content of cobamamide tablets was the best.