In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer |
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Authors: | M Ohashi F Kanai T Tanaka KH Lan Y Shiratori Y Komatsu T Kawabe H Yoshida H Hamada M Omata |
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Affiliation: | Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Japan. mnangaku-tky@umin.ac.jp |
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Abstract: | The vascular endothelial injury with its consequent activation is actively involved in inflammation and promotion of a procoagulant state, which are likely to be of major importance in the pathogenesis of various disorders, including renal thrombotic microangiopathy. This study briefly reviews the consequences of glomerular endothelial cell injury or activation, as shown by recent experimental data. |
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