|
|||||
|
|
Short Chemoenzymatic Azide‐Free Synthesis of Oseltamivir (Tamiflu): Approaching the Potential for Process Efficiency |
|
| Authors: | Lukas Werner Ales Machara Tomas Hudlicky |
| Abstract: | A short chemoenzymatic and azide‐free synthesis of oseltamivir was attained with the key steps consisting of a one‐pot Dauben–Michno oxidative transposition and amination and a reductive transposition of an acrylate. |
| Keywords: | antiviral agents asymmetric synthesis biotransformations oxidative transposition synthesis design tamiflu synthesis |