| L-苯丙氨醇质量控制研究 |
| |
| 引用本文： | 曹佩雪,郭红玲,梁光义,等. L-苯丙氨醇质量控制研究[J]. 广东化工, 2014, 0(8): 11-12 |
| |
| 作者姓名： | 曹佩雪 郭红玲 梁光义 等 |
| |
| 作者单位： | [1]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002 [2]中国人民解放军第三〇二医院,北京100039 [3]天津药物研究院,天津300193 [4]贵州百灵企业集团制药股份有限公司,贵州安顺561000 |
| |
| 基金项目： | “十二五”国家重大新药创制科技重大专项（2011ZX09102-009-002）,贵州省中药现代化科技产业研究开发专项（黔科合中药字[2012]5054）,贵州省创新人才基地（黔人领发[2011]1号） |
| |
| 摘 要： | 建立L-苯丙氨醇质量内控方法。采用反相高效液相色谱法,用Phenomenex Gemini C18(4.6×250 mm,5μm)柱,以乙腈-0.02 mol/L磷酸二氢钾溶液(含0.1%三乙胺)(8∶92)为流动相,在206 nm测定。L-苯丙氨醇在0.01~0.23μg/μL范围内线性关系良好(r=0.9999);回收率为100.30%(RSD=1.60%)。采用比旋光度法控制其光学纯度。
|
| 关 键 词： | L-苯丙氨醇 高效液相色谱法 质量控制 |
Quality Control of L-Phenylalaninol |
| |
| Cao PeixueI,Guo Honglingl,Liang Guangyil,Huang Zhengming,Liu Changxiao,Xia Wen,Hu Zhanxing. Quality Control of L-Phenylalaninol[J]. Guangdong Chemical Industry, 2014, 0(8): 11-12 |
| |
| Authors: | Cao PeixueI Guo Honglingl Liang Guangyil Huang Zhengming Liu Changxiao Xia Wen Hu Zhanxing |
| |
| Affiliation: | 1. The Key laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002： 2. 302 Hospital ofPLA, Beijing 100039; 3. Tianjin Institute of Pharmaceutical Research, Tianjin 300193; 4. Guizhou Bailing Enterprise Group Pharmaceutical CO., Ltd., Anshun 561000, China) |
| |
| Abstract: | To develop the quality standard for L-phenylalaninol. The content of L-phenylalaninol was determined by reversed-phase high performance liquid chromatography（RP-HPLC）with the column of Phenomenex Gemini Ci8（4.6-250mm, 5 p.m） and the mobile phase of acetonitrile：20 mM potassium dihydrogen phosphateat containing 0.1% triethylamine（8 ： 92） at 206 nm. The linear range of L-phenylalaninol was 0.01-0.23μg/μL （r = 0.9999） and the average recovery of L-phenylalaninol was 100.30 %（RSD = 1.60）. The enantiospecific analysis of L-phenylalaninol was monitored by the power rotation. |
| |
| Keywords: | L-phenylalaninol： RP-HPLC quality control |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
