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Carpesium abrotanoides extract inhibits inducible nitric oxide synthase expression induced by toll-like receptor agonists |
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| Authors: | Eun-Kyeong Lee Do-Won Jeong Se Jin Lim Gyo-Jeong Gu Sang-Il Ahn Ji-Soo Kim Ji Hun Paek Songmun Kim Jae Seung Hong Soon Sung Lim Hyung-Sun Youn |
| Affiliation: | 1. Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University, Asan, Chungnam, 336-745, Korea 2. Departments of Medical Science, College of Medical Sciences, SoonChunHyang University, Asan, Chungnam, 336-745, Korea 3. Department of Food Science and Nutrition, Hallym University, Chuncheon, Gangwon, 200-702, Korea 4. Department of Biological Environment, Kangwon National University, Chuncheon, Gangwon, 200-701, Korea 5. Department of Physical Education, Hallym University, Chuncheon, Gangwon, 200-702, Korea |
| Abstract: | Inflammation is a pathological and physiological process which is known to be involved in numerous diseases, while it is notable that a considerable proportion of chronic inflammatory diseases overlap with the development of cancer. One of the most important proteins for inflammatory responses is inducible nitric oxide synthase (iNOS). The present study investigated the effect of the extract of Carpesium abrotanoides L. (ECA) on inflammation by modulating iNOS expression induced by toll-like receptors (TLRs) agonists in murine macrophages. ECA suppressed iNOS expression induced by lipopolysaccharide (TLR4 agonist), macrophage-activating lipopeptide 2-kDa (TLR2 and TLR6 agonist), and polyriboinosinic polyribocytidylic acid (TLR3 agonist). All the results suggest that ECA can modulate TLR signaling pathways and subsequent chronic inflammatory responses. |
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