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Evaluation of Synurus deltoides for antioxidant,antimicrobial, and anti-proliferative activities using In vitro assays |
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| Authors: | Md Abul Hasnat Mehnaz Pervin Yong Chang Jang Young Ock Kim Soojin Park Jong Moon Kim Ji Hong Lim Beong Ou Lim |
| Affiliation: | 1. Department of Applied Biochemistry, College of Biomedical & Health Science, Konkuk University, Chungju, Chungbuk, 380-701, Korea 2. Department of Herbal Crop Research, NIHHS, RDA, Eumseong, Chungbuk, 369-873, Korea 3. Department of Life Science, College of Biomedical & Health Science, Konkuk University, Chungju, Chungbuk, 380-701, Korea 4. Department of Rehabilitation Medicine, Konkuk University Chungju Hospital, Chungju, Chungbuk, 380-701, Korea |
| Abstract: | The antioxidant, antimicrobial, and anti-proliferative activities of water and ethanol extracts from leaves of Synurus deltoides (SD) were investigated. Extracts showed strong reductive powers, nitrite-scavenging activities, DPPH, ABTS, hydroxyl, and superoxide radical scavenging activities, and DNA damage prevention activities. SD extracts also showed strong cellular antioxidant activities in a dose-dependent manner with IC50 values of 0.93 and 0.65 mg/mL for water and ethanol extracts, respectively. Antimicrobial activities were evaluated against 4 microorganisms. SD extracts showed high inhibitory activities against Pseudomonas aeruginosa and Staphylococcus aureus. The anti-proliferative activity was dose-dependent against human colon adenocarcinoma (HT-29) and mouse rectum carcinoma cells (CMT-93). In addition, HPLC analyses of SD leaf extracts revealed the presence of different phenolic compounds. SD can be considered as a source of functional foods and pharmaceuticals. |
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