Turnover of bile acids in the hypercholesterolemic rat as influenced by saturation of dietary fat |
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Authors: | R F Mcgovern F W Quackenbush |
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Affiliation: | (1) Department of Biochemistry, Purdue University, 47907 West Lafayette, Indiana;(2) Present address: Tompkins County Hospital Laboratory, 14810 Ithaca, N.Y. |
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Abstract: | Injections of 24-14C] chenodeoxycholate and3H-cholate were made by heart puncture into 300 g male rats that bore T-cannulas in their bile ducts. The animals had been
raised on diet A, containing glucose, cholesterol and cholate, or diet B, containing sucrose and cholesterol; each of the
diets contained 5% safflower oil or 5% beef tallow as variables. From analysis of bile samples collected from the T at intervals
over a 5 day period, it was observed that the safflower oil group fed diet B had a 17% shorter cholate half-life, a 29% larger
cholate pool size and 52% higher rate of cholate synthesis than those fed beef tallow in the same diet. The safflower group
fed diet A also had a larger cholate pool size, but synthesis and half-life were obscured by cholate feeding. Chenodeoxycholate
turnover data were not obtainable because the decay curves were bimodal for all treatments and hence did not conform to a
simple pool model. It is concluded that dietary safflower oil causes more rapid formation of cholate than does dietary beef
tallow in the cholesterol-fed rat.
Journal Paper No. 4952 AES, Purdue University. |
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