Delayed release matrix pellet preparation containing an alkalizing pore-former agent |
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Authors: | Elnazeer I. HamedelnielJá nos Bajdik,Tamá s Sová nyKlá ra Pintye-Hó di |
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Affiliation: | Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary |
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Abstract: | The aim of this study was to develop a delayed-release matrix pellet containing atenolol as active pharmaceutical ingredient. The matrix additionally contained trisodium phosphate dodecahydrate as alkalizing pore-former agent to enhance the dissolution of the atenolol at pH 6.8. The delayed release was ensured by coating with a gastro-resistant polymer. For this purpose, an acryl EZE MP aqueous dispersion was used, which is suggested in the literature for pellet coating. Before this functional film coating, a protective polymer layer was developed, to prevent direct contact between the alkalizing layer and the acryl EZE. The results of in vitro dissolution tests demonstrated that the double-coated pellet preparation is a delayed-release solid dosage form. |
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Keywords: | Matrix pellet Pore-former agent Coating Dissolution test Delayed release |
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